Detalhes do Artigo
[306138] Development of Certified Reference Material of methamphetamine hydrochloride
Autores: Silvia Regina Pinheiro Lopes, Wagner Wollinger, Eliane Cristina Pires do Rego, Bruno Carius Garrido
Resumo: This work aimed to present the production of certified reference material (CRM) of methamphetamine hydrochloride, as an important tool to ensure the quality of forensic results. Methamphetamine is a synthetic drug derived from amphetamine, which potentially stimulates the central nervous system, and its prolonged use can cause excessive anxiety, euphoria, bipolar disorder, psychosis, among other health damages. To produce this batch of CRM, homogeneity and transport stability studies were carried out by HPLC-PDA using the results of chromatographic area corrected by the mass fraction of the sample in the analyzed solution. Evaluation of stability under storage conditions and characterization of the material were performed by 1H qNMR, a primary measurement procedure. The CRM showed neither considerable heterogeneity nor tendency to instability under transport conditions (temperature of 50 ºC up to 21 days) and storage conditions (20-25 °C). The certified purity value of methamphetamine hydrochloride was (999 ± 12) mg/g, equivalent to a mass fraction of (99.9 ± 1.2) g/100g (k = 2).